Gold nanoparticles-loaded contact lenses for laser protection and Meibomian Gland Dysfunction (MGD) dry eye treatment

Laser based devices are ubiquitous in many fields which has resulted an increase ocular injuries from laser exposure. Glasses for protection available but contact lenses that block certain wavelengths could be a less bulky alternative. Here, we focus on developing lens protecting eyes accidental exposure to green by incorporation of gold nanoparticles exhibit local maximum absorbance as tunable wavelength due the localized surface plasmon resonance (LSPR) effect. The particles incorporated poly vinyl alcohol (PVA) because PVA offers twin benefits stabilizing during manufacturing Turkevich method and excellent biocompatibility high-water content. monodispersed desired size (11.75 ± 1.09 nm) were prepared with stabilizer. separated out anti-solvent precipitation then redispersion achieve concentration, finally crosslinked freezing-thawing cycling form loaded (PVA GoldinLens). remain well-dispersed all nanoparticle loadings (0%, 0.25%, 0.5%, 1%, 2% 4%, wt% dried lenses). transmittance spectra GoldinLenses minimum at 520 nm LSPR effect 12 nanoparticles. was reduced entire range, is typical glasses decrease more pronounced around nm. efficacy enhances particle concentration becomes relatively independent loading higher reaching value 66.7%. To further improve protection, explore alternative approach inside two commercial (Acuvue TruEye Moist) soaking precursor solution (0.25–1%, wt%) followed reduction 5% (wt%) sodium borohydride particles. This process leads formation about 100 lenses. Incorporation both superior absorption compared comparable > 90% blocking 3% (wt% lens) loading. However, not tuned larger sizes aggregates result light decreasing significantly range. Based comparing glasses, GoldinLens 0.75% appears good potential In cases, heating damage tissue other hand potentially also useful treating indications warming eyelids beneficial such dry eyes. increases temperature than melting point meibomian lipids critical gland dysfunction (MGD) eye disease heating. work advances field similar gels broad set applications including laser-protection, treatment color blindness.